Chemical dissection of the targets of insecticides with a novel mode of action

Recent developments around tools for target ID in the Tate lab have presented a unique opportunity to profile the targets of pyridalyl (PAL), a potent and selective insecticide of substantial commercial importance. Understanding the targets of this molecule is a high priority for Syngenta and would open up new classes of insecticide target for future exploitation. Addition of a 'clickable' tag to selected inhibitors will facilitate ligation of combinations of biotin and fluorescent dye labels and will enable imaging and pull-down based assays.